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https://hdl.handle.net/2440/132641
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Type: | Journal article |
Title: | J-Aggregate-Based FRET Monitoring of Drug Release from Polymer Nanoparticles with High Drug Loading |
Author: | Liu, Y. Yang, G. Jin, S. Zhang, R. Chen, P. Tengjisi, Wang, L. Chen, D. Weitz, D.A. Zhao, C.X. |
Citation: | Angewandte Chemie International Edition, 2020; 59(45):20065-20074 |
Publisher: | Wiley |
Issue Date: | 2020 |
ISSN: | 1433-7851 1521-3773 |
Statement of Responsibility: | Yun Liu, Guangze Yang, Song Jin, Run Zhang, Peng Chen, Tengjisi, Lianzhou Wang, Dong Chen, David A. Weitz, and Chun-Xia Zhao |
Abstract: | Understanding drug-release kinetics is critical for the development of drug-loaded nanoparticles. We developed a J-aggregate-based Förster-resonance energy-transfer (FRET) method to investigate the release of novel high-drug-loading (50 wt %) nanoparticles in comparison with low-drug-loading (0.5 wt %) nanoparticles. Single-dye-loaded nanoparticles form J-aggregates because of the high dye-loading (50 wt %), resulting in a large red-shift (≈110 nm) in the fluorescence spectrum. Dual-dye-loaded nanoparticles with high dye-loading using FRET pairs exhibited not only FRET but also a J-aggregate red-shift (116 nm). Using this J-aggregate-based FRET method, dye-core-polymer-shell nanoparticles showed two release processes intracellularly: the dissolution of the dye aggregates into dye molecules and the release of the dye molecules from the polymer shell. Also, the high-dye-loading nanoparticles (50 wt %) exhibited a slow release kinetics in serum and relatively quick release in cells, demonstrating their great potential in drug delivery. |
Keywords: | drug release; FRET; J-aggregates; nanoparticles; polymers |
Rights: | © 2020 Wiley-VCH GmbH |
DOI: | 10.1002/anie.202008018 |
Grant ID: | http://purl.org/au-research/grants/arc/FT140100726 http://purl.org/au-research/grants/arc/DP200101238 |
Published version: | http://dx.doi.org/10.1002/anie.202008018 |
Appears in Collections: | Chemical Engineering publications |
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