Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/130352
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Type: Journal article
Title: Multifunctional roles of the actin-binding protein Flightless I in inflammation, cancer and wound healing
Author: Strudwick, X.L.
Cowin, A.J.
Citation: Frontiers in Cell and Developmental Biology, 2020; 8:603508-1-603508-22
Publisher: Frontiers Media
Issue Date: 2020
ISSN: 2296-634X
2296-634X
Statement of
Responsibility: 
Xanthe L. Strudwick and Allison J. Cowin
Abstract: Flightless I is an actin-binding member of the gelsolin family of actin-remodeling proteins that inhibits actin polymerization but does not possess actin severing ability. Flightless I functions as a regulator of many cellular processes including proliferation, differentiation, apoptosis, and migration all of which are important for many physiological processes including wound repair, cancer progression and inflammation. More than simply facilitating cytoskeletal rearrangements, Flightless I has other important roles in the regulation of gene transcription within the nucleus where it interacts with nuclear hormone receptors to modulate cellular activities. In conjunction with key binding partners Leucine rich repeat in the Flightless I interaction proteins (LRRFIP)1/2, Flightless I acts both synergistically and competitively to regulate a wide range of cellular signaling including interacting with two of the most important inflammatory pathways, the NLRP3 inflammasome and the MyD88-TLR4 pathways. In this review we outline the current knowledge about this important cytoskeletal protein and describe its many functions across a range of health conditions and pathologies. We provide perspectives for future development of Flightless I as a potential target for clinical translation and insights into potential therapeutic approaches to manipulate Flightless I functions.
Keywords: Flightless I; actin-binding protein; wound healing; inflammation; cancer
Rights: Copyright © 2020 Strudwick and Cowin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI: 10.3389/fcell.2020.603508
Grant ID: http://purl.org/au-research/grants/nhmrc/GNT1002009
Published version: http://dx.doi.org/10.3389/fcell.2020.603508
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