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dc.contributor.authorJones, N.R.en
dc.contributor.authorHickman, M.en
dc.contributor.authorLarney, S.en
dc.contributor.authorNielsen, S.en
dc.contributor.authorAli, R.en
dc.contributor.authorMurphy, T.en
dc.contributor.authorDobbins, T.en
dc.contributor.authorFiellin, D.A.en
dc.contributor.authorDegenhardt, L.en
dc.identifier.citationDrug and Alcohol Dependence, 2021; 218:108354-1-108354-10en
dc.description.abstractBACKGROUND:To examine, among a cohort of opioid dependent people with a history of opioid agonist treatment (OAT), the frequency and incidence rates of non-fatal overdose (NFOD) hospital separations over time, by age and sex. METHODS:Retrospective cohort study of people with a history of OAT using state-wide linked New South Wales (NSW) data. The incidence of NFOD hospital separations involving an opioid, sedative, stimulant or alcohol was defined according to the singular or combination of poisoning/toxic effect using ICD-10-AM codes. Crude incidence rates were calculated by gender, age group and calendar year. RESULTS:There were 31.8 (31.3-32.3) NFOD per 1,000 person-years (PY). Opioid NFOD incidence was higher in women than men: incidence rate ratio (IRR) 1.11 per 1,000PY; 95 %CI: [1.06-1.17]; women had higher sedative NFOD rates than men, IRR 1.27 per 1,000PY [1.21-1.34]. Participants ≤25 years, 26-30yrs, and 31-35yrs had higher incidence of opioid NFOD compared to 46+yrs, with IRRs of: 1.45 per 1,000PY; [1.32-1.59]; 1.20 per 1,000PY; [1.11-1.30] and 1.22 per 1,000PY; [1.13-1.32], respectively. Between 2006-7 and 2016-17, the cohort accounted for 19 % of NSW opioid NFOD episodes, 12 % of sedative, 14 % of stimulant and 5 % of acute alcohol-related NFOD. CONCLUSIONS:Hospital stays due to NFOD are a relatively frequent occurrence among opioid-dependent people. There are clear differences in rates and substances involved by sex, age and over time. Evidence-based interventions that prevent overdose among people who are opioid dependent need to be delivered to scale, including widespread community provision of naloxone.en
dc.description.statementofresponsibilityNicola R. Jones, Matthew Hickman, Sarah Larney, Suzanne Nielsen, Robert Ali, Thomas Murphy ... et al.en
dc.rights© 2020 Elsevier B.V. All rights reserved.en
dc.subjectOverdose; opioid; amphetamine; alcohol; sedativeen
dc.titleHospitalisations for non-fatal overdose among people with a history of opioid dependence in New South Wales, Australia, 2001-2018: findings from the OATS retrospective cohort studyen
dc.typeJournal articleen
dc.identifier.orcidAli, R. [0000-0003-2905-8153]en
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Psychiatry publications

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