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Type: Journal article
Title: Hospitalisations for non-fatal overdose among people with a history of opioid dependence in New South Wales, Australia, 2001-2018: findings from the OATS retrospective cohort study
Author: Jones, N.R.
Hickman, M.
Larney, S.
Nielsen, S.
Ali, R.
Murphy, T.
Dobbins, T.
Fiellin, D.A.
Degenhardt, L.
Citation: Drug and Alcohol Dependence, 2021; 218:108354-1-108354-10
Publisher: Elsevier
Issue Date: 2021
ISSN: 0376-8716
Statement of
Nicola R. Jones, Matthew Hickman, Sarah Larney, Suzanne Nielsen, Robert Ali, Thomas Murphy ... et al.
Abstract: BACKGROUND:To examine, among a cohort of opioid dependent people with a history of opioid agonist treatment (OAT), the frequency and incidence rates of non-fatal overdose (NFOD) hospital separations over time, by age and sex. METHODS:Retrospective cohort study of people with a history of OAT using state-wide linked New South Wales (NSW) data. The incidence of NFOD hospital separations involving an opioid, sedative, stimulant or alcohol was defined according to the singular or combination of poisoning/toxic effect using ICD-10-AM codes. Crude incidence rates were calculated by gender, age group and calendar year. RESULTS:There were 31.8 (31.3-32.3) NFOD per 1,000 person-years (PY). Opioid NFOD incidence was higher in women than men: incidence rate ratio (IRR) 1.11 per 1,000PY; 95 %CI: [1.06-1.17]; women had higher sedative NFOD rates than men, IRR 1.27 per 1,000PY [1.21-1.34]. Participants ≤25 years, 26-30yrs, and 31-35yrs had higher incidence of opioid NFOD compared to 46+yrs, with IRRs of: 1.45 per 1,000PY; [1.32-1.59]; 1.20 per 1,000PY; [1.11-1.30] and 1.22 per 1,000PY; [1.13-1.32], respectively. Between 2006-7 and 2016-17, the cohort accounted for 19 % of NSW opioid NFOD episodes, 12 % of sedative, 14 % of stimulant and 5 % of acute alcohol-related NFOD. CONCLUSIONS:Hospital stays due to NFOD are a relatively frequent occurrence among opioid-dependent people. There are clear differences in rates and substances involved by sex, age and over time. Evidence-based interventions that prevent overdose among people who are opioid dependent need to be delivered to scale, including widespread community provision of naloxone.
Keywords: Overdose; opioid; amphetamine; alcohol; sedative
Rights: © 2020 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.drugalcdep.2020.108354
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Psychiatry publications

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