Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/128346
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Linking data from a large clinical trial with the Australian Cerebral Palsy Register |
Author: | Shepherd, E. Mcintyre, S. Smithers-Sheedy, H. Ashwood, P. Sullivan, T.R. Te Velde, A. Doyle, L.W. Makrides, M. Middleton, P. Crowther, C.A. |
Citation: | Developmental Medicine and Child Neurology, 2020; 62(10):1170-1175 |
Publisher: | Wiley |
Issue Date: | 2020 |
ISSN: | 0012-1622 1469-8749 |
Statement of Responsibility: | Emily Shepherd, Sarah Mcintyre, Hayley Smithers-Sheedy, Pat Ashwood, Thomas R Sullivan, Anna te Velde, Lex W Doyle, Maria Makrides, Philippa Middleton, Caroline A Crowther |
Abstract: | Aim: To link data from a large maternal perinatal trial with the Australian Cerebral Palsy Register (ACPR) to identify children with cerebral palsy (CP). Method: Deidentified data from the Australasian Collaborative Trial of Magnesium Sulphate (ACTOMgSO₄ ) and the ACPR were linked. Children born from 1996 to 2000 at Australian hospitals who survived and had 2-year paediatric assessments were included. Children identified with CP in: (1) both the ACTOMgSO₄ (2y) and the ACPR (5y), (2) the ACTOMgSO₄ only, and (3) the ACPR only were compared. Results: We included 913 children (492 males, 421 females; mean gestational age at birth 27.8wks [standard deviation 2.1wks]; range 23.0-40.0wks). Eighty-four children received a CP diagnosis: 35 by the ACTOMgSO₄ and the ACPR, 29 by the ACTOMgSO₄ only, and 20 by the ACPR only. The ACTOMgSO₄ diagnosed 76.2% (95% confidence interval [CI] 65.9-84.1) and the ACPR identified 65.5% (95% CI 54.7-74.9). Children born in states/territories with long-standing versus more recently established registers were more likely to be included on the ACPR (p<0.05). Interpretation: Linking deidentified perinatal trial data with the ACPR was achieved. Limitations of both strategies for identifying children with CP in this era (late 1990s and early 2000s) probably explain many of the differences observed, and inform future linkage studies and evaluations of CP-preventive interventions. |
Keywords: | Humans Cerebral Palsy Magnesium Sulfate Registries Gestational Age Pregnancy Information Storage and Retrieval Child, Preschool Infant, Newborn Infant, Premature Australia Female Male Randomized Controlled Trials as Topic |
Rights: | © 2020 Mac Keith Press |
DOI: | 10.1111/dmcn.14556 |
Published version: | http://dx.doi.org/10.1111/dmcn.14556 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.