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dc.contributor.authorLiu, Y.en
dc.contributor.authorWeyrich, L.S.en
dc.contributor.authorLlamas, B.en
dc.identifier.citationMolecular biology and evolution, 2020; 37(2):307-319en
dc.description.abstractWhether and how epigenetic mechanisms and the microbiome play a role in mammalian adaptation raised considerable attention and controversy, mainly because they have the potential to add new insights into the Modern Synthesis. Recent attempts to reconcile neo-Darwinism and neo-Lamarckism in a unified theory of molecular evolution give epigenetic mechanisms and microbiome a prominent role. However, supporting empirical data is still largely missing. Because experimental studies using extant animals can hardly be done over evolutionary timescales, we propose that advances in ancient DNA techniques provide a valid alternative. In this piece, we evaluate: (1) the possible roles of epigenomes and microbiomes in animal adaptation; (2) advances in the retrieval of paleoepigenome and paleomicrobiome data using ancient DNA techniques; and (3) the plasticity of either and interactions between the epigenome and the microbiome, while emphasising that it is essential to take both into account, as well as the underlying genetic factors that may confound the findings. We propose that advanced ancient DNA techniques should be applied to a wide range of past animals, so novel dynamics in animal evolution and adaption can be revealed.en
dc.description.statementofresponsibilityYichen Liu, Laura S Weyrich, Bastien Llamasen
dc.publisherOxford Academic Pressen
dc.rights© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (
dc.subjectAncient DNA; animal evolution; paleoepigenome; paleomicrobiomeen
dc.titleMore arrows in the ancient DNA quiver: use of paleoepigenomes and paleomicrobiomes to investigate animal adaptation to environmenten
dc.typeJournal articleen
pubs.library.collectionEnvironment Institute publicationsen
dc.identifier.orcidLlamas, B. [0000-0002-5550-9176]en
Appears in Collections:Environment Institute publications

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