Adelaide Research & Scholarship
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https://hdl.handle.net/2440/121989
| Type: | Thesis |
| Title: | The common signalling subunit, hβc in the myeloproliferative disorder, Polycythemia vera |
| Author: | Butcher, Carolyn Marie |
| Issue Date: | 2003 |
| School/Discipline: | Dept. of Medicine |
| Abstract: | Aims to determine whether mutations of the gene encoding hβc (CSF2RB) are present in Polycythemia vera. Two possible PV specific single nucleotide substitutions were detected that result in non-conservative amino acid substitutions, F451S and R472I, within the transmembrane and the intracytopasmic box 1 motifs of hβc, Discusses the potential significance of these alterations with regard to receptor signalling and PV. In addition, an alternatively-spliced variant of hβc ([delta]1041-1045) was identified in both normal and PV patient samples. This mRNA species encodes a truncated, soluble form of the receptor and is expressed at a low level in PBMNC. |
| Dissertation Note: | Thesis (M.Med.Sc.) -- University of Adelaide, Dept. of Medicine, 2003. |
| Keywords: | Cellular signal transduction Hematopoietic growth factors Polycythemia vera -- Genetics |
| Provenance: | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals |
| Appears in Collections: | Research Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Butcher2003_MMSc.pdf | 9.11 MB | Adobe PDF | View/Open |
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