Inter-individual variability in platelet adenylate and soluble guanylate cyclase signaling: therapeutic perspectives

Abstract

Variability in integrity of platelet prostanoid adenylate cyclase signaling: pathogenetic and therapeutic implication The prostanoid-adenylate cyclase (PG/AC) signaling system plays a major role in inhibiting platelet aggregation and resultant thrombosis. In the studies carried out in this thesis, it was shown that: - (a) Integrity of PG/AC signaling exerts a major influence of individual responses to inhibitors of the P2Y12 receptor. (b) Patients with threatened myocardial infarction have impairment of PG/AC signaling relative to normals. (c) Coronary artery spasms (CAS) is associated with impairment of both PG/AC and nitric oxide signaling, which may be pivotal to occurrence of CAS. (d) PG/AC signaling is potentiated by the anti-anginal agent perhexiline.