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Type: Journal article
Title: Catalytic enantioselective transformations involving C-H bond cleavage by transition-metal complexes
Author: Newton, C.
Wang, S.
Oliveira, C.
Cramer, N.
Citation: Chemical Reviews, 2017; 117(13):8908-8976
Publisher: American Chemical Society
Issue Date: 2017
ISSN: 0009-2665
Statement of
Christopher G. Newton, Shou-Guo Wang, Caio C. Oliveira and Nicolai Cramer
Abstract: The development of new methods for the direct functionalization of unactivated C-H bonds is ushering in a paradigm shift in the field of retrosynthetic analysis. In particular, the catalytic enantioselective functionalization of C-H bonds represents a highly atom- and step-economic approach toward the generation of structural complexity. However, as a result of their ubiquity and low reactivity, controlling both the chemo- and stereoselectivity of such processes constitutes a significant challenge. Herein we comprehensively review all asymmetric transition-metal-catalyzed methodologies that are believed to proceed via an inner-sphere-type mechanism, with an emphasis on the nature of stereochemistry generation. Our analysis serves to document the considerable and rapid progress within in the field, while also highlighting limitations of current methods.
Rights: © 2017, American Chemical Society
DOI: 10.1021/acs.chemrev.6b00692
Appears in Collections:Aurora harvest 3
Chemical Engineering publications

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