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https://hdl.handle.net/2440/115602
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dc.contributor.author | Ganella, E. | - |
dc.contributor.author | Seguin, C. | - |
dc.contributor.author | Pantelis, C. | - |
dc.contributor.author | Whittle, S. | - |
dc.contributor.author | Baune, B. | - |
dc.contributor.author | Olver, J. | - |
dc.contributor.author | Amminger, G. | - |
dc.contributor.author | McGorry, P. | - |
dc.contributor.author | Cropley, V. | - |
dc.contributor.author | Zalesky, A. | - |
dc.contributor.author | Bartholomeusz, C. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Australian and New Zealand Journal of Psychiatry, 2018; 52(9):864-875 | - |
dc.identifier.issn | 0004-8674 | - |
dc.identifier.issn | 1440-1614 | - |
dc.identifier.uri | http://hdl.handle.net/2440/115602 | - |
dc.description.abstract | Introduction: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, reports of network abnormalities during the early illness stage of psychosis are mixed. This study adopted a data-driven whole-brain approach to investigate functional connectivity and network architecture in a first-episode psychosis cohort relative to healthy controls and whether functional network properties changed abnormally over a 12-month period in first-episode psychosis. Methods: Resting-state functional connectivity was performed at two time points. At baseline, 29 first-episode psychosis individuals and 30 healthy controls were assessed, and at 12 months, 14 first-episode psychosis individuals and 20 healthy controls completed follow-up. Whole-brain resting-state functional connectivity networks were mapped for each individual and analyzed using graph theory to investigate whether network abnormalities associated with first-episode psychosis were evident and whether functional network properties changed abnormally over 12 months relative to controls. Results: This study found no evidence of abnormal resting-state functional connectivity or topology in first-episode psychosis individuals relative to healthy controls at baseline or at 12-months follow-up. Furthermore, longitudinal changes in network properties over a 12-month period did not significantly differ between first-episode psychosis individuals and healthy control. Network measures did not significantly correlate with symptomatology, duration of illness or antipsychotic medication. Conclusions: This is the first study to show unaffected resting-state functional connectivity and topology in the early psychosis stage of illness. In light of previous literature, this suggests that a subgroup of first-episode psychosis individuals who have a neurotypical resting-state functional connectivity and topology may exist. Our preliminary longitudinal analyses indicate that there also does not appear to be deterioration in these network properties over a 12-month period. Future research in a larger sample is necessary to confirm our longitudinal findings. | - |
dc.description.statementofresponsibility | Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky and Cali F Bartholomeusz | - |
dc.language.iso | en | - |
dc.publisher | SAGE Publications | - |
dc.rights | © The Royal Australian and New Zealand College of Psychiatrists 2018 | - |
dc.source.uri | http://dx.doi.org/10.1177/0004867418775833 | - |
dc.subject | Resting state | - |
dc.subject | first episode of psychosis | - |
dc.subject | functional connectivity | - |
dc.subject | graph theory | - |
dc.title | Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1177/0004867418775833 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/628386 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1105825 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1047648 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1007716 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Baune, B. [0000-0001-6548-426X] | - |
Appears in Collections: | Aurora harvest 8 Psychiatry publications |
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