Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/115583
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Role of intestinal bitter sensing in enteroendocrine hormone secretion and metabolic control |
Author: | Xie, C. Wang, X. Young, R.L. Horowitz, M. Rayner, C.K. Wu, T. |
Citation: | Frontiers in Endocrinology, 2018; 9:576-1-576-10 |
Publisher: | Frontiers Media |
Issue Date: | 2018 |
ISSN: | 1664-2392 1664-2392 |
Statement of Responsibility: | Cong Xie, Xuyi Wang, Richard L. Young, Michael Horowitz, Christopher K. Rayner and Tongzhi Wu |
Abstract: | The gastrointestinal tract stores ingested nutrients in the stomach which are then delivered to the small intestine at a controlled rate to optimize their digestion and absorption. The interaction of nutrients with the small and large intestine generates feedback that slows gastric emptying, induces satiation, and reduces postprandial glycemic excursions. The mechanisms underlying these nutrient-gut interactions are complex; it has only recently been appreciated that the gut has the capacity to detect intraluminal contents in much the same way as the tongue, via activation of specific G-protein-coupled receptors, and that ensuing signaling mechanisms modulate the release of an array of gut hormones that influence gastrointestinal motility, appetite and glycemia. Interestingly, evidence from preclinical models supports a functional link between intestinal bitter taste receptor (BTRs) and gastrointestinal hormone secretion, and the outcomes of recent studies indicate that stimulation of intestinal BTRs may be used to modulate gastrointestinal function, to diminish energy intake and limit postprandial blood glucose excursions in humans. This review summarizes current evidence about the expression and function of intestinal BTRs in relation to enteroendocrine hormone release and discusses the clinical implications of this pathway for the management of obesity and type 2 diabetes. |
Keywords: | bitter taste receptors gut hormones enteroendocrine cells energy intake blood glucose obesity type 2 diabetes |
Description: | Published: 27 September 2018 |
Rights: | Copyright © 2018 Xie, Wang, Young, Horowitz, Rayner and Wu. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
DOI: | 10.3389/fendo.2018.00576 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1147333 |
Published version: | http://dx.doi.org/10.3389/fendo.2018.00576 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_115583.pdf | Published version | 915.01 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.