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Type: Theses
Title: An immunological perspective of the mucosal inflammation in chronic rhinosinusitis – lymphoid neo-organogenesis and humoral immunity
Author: Lau, Aden Ho Yin
Issue Date: 2018
School/Discipline: Adelaide Medical School
Abstract: Chronic rhinosinusitis (CRS) is defined by the symptomatic inflammation of the nose and paranasal sinuses longer than 12 weeks. These symptoms include nasal discharge, nasal obstruction, facial pain and pressure, leading to a substantial impact on the quality of life of CRS patients. CRS can be phenotypically classified into either CRS without nasal polyps (CRSsNP) or CRS with nasal polyps (CRSwNP), based on the presence of endoscopically visualized nasal polyps in the middle meatus. Interestingly, ectopic accumulations of lymphoid cells are often observed within the nasal polyps of CRSwNP. This raises the question as to whether these aberrant lymphoid cell aggregates play a role in orchestrating the perpetual inflammation in CRS. Studies in the past have identified the increased amount of local class-switched antibodies in nasal polyps, but few studies have investigated the source of these immunoglobulins and utilized specific markers to study the presence of the organized lymphoid structures and their relation to disease severity in the context of CRS. This thesis investigates the significance of organized lymphoid neo-organogenesis in CRS pathogenesis and its effect on humoral immunity within both CRSsNP and CRSwNP patients.
Advisor: Vreugde, Sarah
Lester, Susan
Rischmueller, Maureen
Dissertation Note: Thesis (Ph.D.) (Research by Publication) -- University of Adelaide, Adelaide Medical School, 2018
Keywords: Research by publication
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at
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