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https://hdl.handle.net/2440/114160
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Type: | Journal article |
Title: | Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity |
Author: | Neumann, D.P. Goodall, G.J. Gregory, P.A. |
Citation: | Seminars in Cell and Developmental Biology, 2018; 75:50-60 |
Publisher: | Elsevier |
Issue Date: | 2018 |
ISSN: | 1084-9521 1096-3634 |
Statement of Responsibility: | Daniel P.Neumann, Gregory J.Goodall, Philip A.Gregory |
Abstract: | Interconversions between epithelial and mesenchymal states, often referred to as epithelial mesenchymal transition (EMT) and its reverse MET, play important roles in embryonic development and are recapitulated in various adult pathologies including cancer progression. These conversions are regulated by complex transcriptional and post-transcriptional mechanisms including programs of alternative splicing which are orchestrated by specific splicing factors. This review will focus on the latest developments in our understanding of the splicing factors regulating epithelial mesenchymal plasticity associated with cancer progression and the induction of pluripotency, including potential roles for circular RNAs (circRNAs) which have been recently implicated in these processes. |
Keywords: | Alternative splicing Circular RNA Epithelial-mesenchymal transition |
Rights: | © 2017 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.semcdb.2017.08.008 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1068773 http://purl.org/au-research/grants/nhmrc/1026191 http://purl.org/au-research/grants/nhmrc/1118170 http://purl.org/au-research/grants/nhmrc/1128479 |
Published version: | http://dx.doi.org/10.1016/j.semcdb.2017.08.008 |
Appears in Collections: | Aurora harvest 3 Molecular and Biomedical Science publications |
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