Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/113564
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dc.contributor.authorPearson-Dennett, V.en
dc.contributor.authorTodd, G.en
dc.contributor.authorWilcox, R.en
dc.contributor.authorVogel, A.en
dc.contributor.authorWhite, J.en
dc.contributor.authorThewlis, D.en
dc.date.issued2017en
dc.identifier.citationDrug and Alcohol Dependence, 2017; 178:215-222en
dc.identifier.issn0376-8716en
dc.identifier.issn1879-0046en
dc.identifier.urihttp://hdl.handle.net/2440/113564-
dc.descriptionAvailable online 21 June 2017en
dc.description.abstractDespite evidence that cannabinoid receptors are located in movement-related brain regions (e.g., basal ganglia, cerebral cortex, and cerebellum), and that chronic cannabis use is associated with structural and functional brain changes, little is known about the long-term effect of cannabis use on human movement. The aim of the current study was to investigate balance and walking gait in adults with a history of cannabis use. We hypothesised that cannabis use is associated with subtle changes in gait and balance that are insufficient in magnitude for detection in a clinical setting.Cannabis users (n=22, 24±6years) and non-drug using controls (n=22, 25±8years) completed screening tests, a gait and balance test (with a motion capture system and in-built force platforms), and a clinical neurological examination of movement.Compared to controls, cannabis users exhibited significantly greater peak angular velocity of the knee (396±30 versus 426±50°/second, P=0.039), greater peak elbow flexion (53±12 versus 57±7°, P=0.038) and elbow range of motion (33±13 versus 36±10°, P=0.044), and reduced shoulder flexion (41±19 versus 26±16°, P=0.007) during walking gait. However, balance and neurological parameters did not significantly differ between the groups.The results suggest that history of cannabis use is associated with long-lasting changes in open-chain elements of walking gait, but the magnitude of change is not clinically detectable. Further research is required to investigate if the subtle gait changes observed in this population become more apparent with aging and increased cannabis use.en
dc.description.statementofresponsibilityVerity Pearson-Dennett, Gabrielle Todd, Robert A. Wilcox, Adam P. Vogel, Jason M. White, Dominic Thewlisen
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2017 Elsevier B.V. All rights reserved.en
dc.subjectCannabis; Biomechanics; Gait analysis; Kinematics; Kineticsen
dc.titleHistory of cannabis use is associated with altered gaiten
dc.typeJournal articleen
dc.identifier.rmid0030072240en
dc.identifier.doi10.1016/j.drugalcdep.2017.05.017en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/627003en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1082910en
dc.identifier.pubid358779-
pubs.library.collectionOrthopaedics and Trauma publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidThewlis, D. [0000-0001-6614-8663]en
Appears in Collections:Orthopaedics and Trauma publications

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