Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11340
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Type: Journal article
Title: The maculatin peptides from the skin glands of the tree frog litoria genimaculata: a comparison of the structures and antibacterial activities of Maculatin 1.1 and Caerin 1.1
Author: Rozek, T.
Waugh, R.
Steinborner, S.
Bowie, J.
Tyler, M.
Wallace, J.
Citation: Journal of Peptide Science, 1998; 4(2):111-115
Publisher: JOHN WILEY & SONS LTD
Issue Date: 1998
ISSN: 1075-2617
1099-1387
Statement of
Responsibility: 
Tomas Rozek, Russell J. Waugh, Simon T. Steinborner, John H. Bowie, Michael J. Tyler, John C. Wallace
Abstract: Six peptides have been isolated and characterized from the dorsal glands of the tree frog Litoria genimaculata. One of these is the known hypotensive peptide caerulein; the others have been named maculatins. The amino acid sequences of the maculatin peptides have been determined using a combination of fast atom bombardment mass spectrometry and automated Edman sequencing. Four of the maculatin peptides show antibiotic activity, with maculatin 1.1 [GLFGVLAKVAAHVVPAIAEHF(NH2)] showing the most pronounced activity, particularly against gram-positive organisms. Maculatin 1.1 resembles the known caerin 1 antibiotic peptides, except that four of the central amino acid residues (of the caerin 1 system) are missing in maculatin 1.1. A comparison of the antibiotic activity of maculatin 1.1 with those of caerin 1.1 is reported.
Keywords: Litoria genimaculata; skin glands; glandular secretions; peptides; antibiotic activity; maculatins 1; caerin 1.1
Rights: © 1998 European Peptide Society and John Wiley & Sons, Ltd.
RMID: 0030004376
DOI: 10.1002/(SICI)1099-1387(199804)4:2<111::AID-PSC134>3.0.CO;2-8
Appears in Collections:Biochemistry publications

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