Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/113087
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nguyen, Q. | - |
dc.contributor.author | Debreceni, T. | - |
dc.contributor.author | Burgess, J. | - |
dc.contributor.author | Bellon, M. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Standfield, S. | - |
dc.contributor.author | Malbert, C.-H. | - |
dc.contributor.author | Horowitz, M. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | International Journal of Obesity, 2018; 42(9):1556-1564 | - |
dc.identifier.issn | 0307-0565 | - |
dc.identifier.issn | 1476-5497 | - |
dc.identifier.uri | http://hdl.handle.net/2440/113087 | - |
dc.description | Published online: 30 January 2018 | - |
dc.description.abstract | Objective: This study evaluated gastric emptying (GE) and small intestinal (SI) transit in people with morbid obesity and their relationships to glycaemia, incretin hormones, and glucose absorption Methods: GE and caecal arrival time (CAT) of a mixed meal were assessed in 22 morbidly obese (50.2 ± 2.5 years; 13 F:9 M; BMI: 48.6 ± 1.8 kg/m2) and 10 lean (38.6 ± 8.4 years; 5 F:5 M; BMI: 23.9 ± 0.7 kg/m2) subjects, using scintigraphy. Blood glucose, plasma 3-O-methylglucose, insulin, glucagon, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) were measured. Insulin sensitivity and resistance were also quantified Results: When compared with lean subjects, GE (t50: 60.7 ± 6.5 vs. 41.1 ± 7.3 min; P = 0.04) and CAT (221.5 ± 9.8 vs. 148.0 ± 7.1 min; P = 0.001) of solids were prolonged in morbid obesity. Postprandial rises in GIP (P = 0.001), insulin (P = 0.02), glucose (P = 0.03) and 3-O-methylglucose (P = 0.001) were less. Whereas GLP-1 increased at 45 mins postprandially in lean subjects, there was no increase in the obese (P = 0.04). Both fasting (P = 0.045) and postprandial (P = 0.012) plasma glucagon concentrations were higher in the obese Conclusions: GE and SI transit are slower in the morbidly obese, and associated with reductions in postprandial glucose absorption, and glycaemic excursions, as well as plasma GIP and GLP-1 | - |
dc.description.statementofresponsibility | Nam Q Nguyen, Tamara L Debreceni, Jenna E Burgess, Max Bellon, Judith Wishart, Scott Standfield, Charles-Henri Malbert, Michael Horowitz | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © Macmillan Publishers Limited, part of Springer Nature 2018 | - |
dc.source.uri | http://dx.doi.org/10.1038/s41366-018-0012-6 | - |
dc.subject | Intestine, Small | - |
dc.subject | Humans | - |
dc.subject | Obesity, Morbid | - |
dc.subject | Gastrointestinal Hormones | - |
dc.subject | Blood Glucose | - |
dc.subject | Radionuclide Imaging | - |
dc.subject | Gastrointestinal Transit | - |
dc.subject | Gastric Emptying | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Impact of gastric emptying and small intestinal transit on blood glucose, intestinal hormones, glucose absorption in the morbidly obese | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/s41366-018-0012-6 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Nguyen, Q. [0000-0002-1270-5441] | - |
dc.identifier.orcid | Malbert, C.-H. [0000-0002-0665-4545] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.