Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/112099
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Type: | Journal article |
Title: | The emerging complexity of γδT17 cells |
Other Titles: | The emerging complexity of gamma deltaT17 cells |
Author: | McKenzie, D. Comerford, I. Silva-Santos, B. McColl, S. |
Citation: | Frontiers in Immunology, 2018; 9(APR):796-1-796-13 |
Publisher: | Frontiers Media |
Issue Date: | 2018 |
ISSN: | 1664-3224 1664-3224 |
Statement of Responsibility: | Duncan R. McKenzie, Iain Comerford, Bruno Silva-Santos and Shaun R. McColl |
Abstract: | Preprogrammed IL-17-producing γδ T cells constitute a poorly understood class of lymphocytes that express rearranged antigen receptors but appear to make little use of them. γδT17 cells were first characterized as tissue-resident sentinels with innate effector function. However, ongoing research continues to reveal unexpected complexity to this unusual subset, including phenotypic plasticity, memory-like activity and unique migratory behavior. Despite these advances, at the core of γδT17 cell biology remain fundamental gaps in knowledge: Are γδT17 cells truly innate or has the importance of the T cell receptor been overlooked? How unique are they among IL-17-producing lymphocytes? How similar are these cells between mice and humans? We speculate that answering these unresolved questions is key to successful manipulation of γδ T cells in clinical settings. |
Keywords: | γδ T cells IL-17 T cell receptor signaling migration plasticity immunological memory translation |
Description: | Published: 20 April 2018 |
Rights: | Copyright © 2018 McKenzie, Comerford, Silva-Santos and McColl. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
DOI: | 10.3389/fimmu.2018.00796 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1066781 |
Published version: | http://dx.doi.org/10.3389/fimmu.2018.00796 |
Appears in Collections: | Aurora harvest 8 Molecular and Biomedical Science publications |
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hdl_112099.pdf | Published version | 1.8 MB | Adobe PDF | View/Open |
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