Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/111551
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Type: Journal article
Title: Metal-organic frameworks for cell and virus biology: a perspective
Author: Riccò, R.
Liang, W.
Li, S.
Gassensmith, J.
Caruso, F.
Doonan, C.
Falcaro, P.
Citation: ACS Nano, 2018; 12(1):13-23
Publisher: American Chemical Society
Issue Date: 2018
ISSN: 1936-0851
1936-086X
Statement of
Responsibility: 
Raffaele Ricco, Weibin Liang, Shaobo Li, Jeremiah J. Gassensmith, Frank Caruso, Christian Doonan and Paolo Falcaro
Abstract: Metal-organic frameworks (MOFs) are a class of coordination polymers, consisting of metal ions or clusters linked together by chemically mutable organic groups. In contrast to zeolites and porous carbons, MOFs are constructed from a building block strategy that enables molecular level control of pore size/shape and functionality. An area of growing interest in MOF chemistry is the synthesis of MOF-based composite materials. Recent studies have shown that MOFs can be combined with biomacromolecules to generate novel biocomposites. In such materials, the MOF acts as a porous matrix that can encapsulate enzymes, oligonucleotides, or even more complex structures that are capable of replication/reproduction (i.e., viruses, bacteria, and eukaryotic cells). The synthetic approach for the preparation of these materials has been termed "biomimetic mineralization", as it mimics natural biomineralization processes that afford protective shells around living systems. In this Perspective, we focus on the preparation of MOF biocomposites that are composed of complex biological moieties such as viruses and cells and canvass the potential applications of this encapsulation strategy to cell biology and biotechnology.
Keywords: Cells, Immobilized
Animals
Humans
Viruses
Enzymes, Immobilized
Oligonucleotides
Biotechnology
Biomimetics
Regenerative Medicine
Porosity
Models, Molecular
Biomimetic Materials
Cell- and Tissue-Based Therapy
Metal-Organic Frameworks
Rights: © 2018 American Chemical Society
DOI: 10.1021/acsnano.7b08056
Grant ID: http://purl.org/au-research/grants/arc/DP170103531
Published version: http://dx.doi.org/10.1021/acsnano.7b08056
Appears in Collections:Aurora harvest 8
Physics publications

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