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Type: Journal article
Title: Plasma atrial natriuretic peptide in patients with acute myocardial infarction: effects of streptokinase
Author: Phillips, P.
Sasadeus, J.
Hodsman, G.
Horowitz, J.
Saltups, A.
Johnston, C.
Citation: Heart, 1989; 61(2):139-143
Publisher: BMJ Publishing Group
Issue Date: 1989
ISSN: 0007-0769
Statement of
P A Phillips, J Sasadeus, G P Hodsman, J Horowitz, A Saltups, C I Johnston
Abstract: Plasma concentrations of immunoreactive atrial natriuretic peptide (mean (SEM] were measured in 135 patients admitted to two coronary care units with myocardial infarction, ischaemic chest pain, or non-ischaemic chest pain. Concentrations were significantly higher in patients with acute myocardial infarction not treated with systemic thrombolysis (60.4 (14.3) pg/ml) than in patients with non-ischaemic chest pain (21.1 (4.3) pg/ml). Patients with ischaemic chest pain had intermediate values (39.3 (7.1) pg/ml). Patients with acute myocardial infarction treated with intravenous streptokinase had normal concentrations of plasma atrial natriuretic peptide (20.2 (3.6) pg/mg), which were significantly lower than those in patients with myocardial infarction not given streptokinase. These changes could not be explained by factors such as age, pre-existing hypertension, renal dysfunction, or cardiac failure, nor treatment other than streptokinase. Raised plasma concentrations of atrial natriuretic peptide in acute myocardial infarction may be a homoeostatic response acting to reduce atrial pressures by natriuresis, diuresis, and venodilatation. The lower concentrations of atrial natriuretic peptide in patients with acute myocardial infarction treated with streptokinase may reflect a short term beneficial haemodynamic effect of streptokinase.
Keywords: Atrial Natriuretic Factor
Description: Published Online First: 01 Sep 1989.
Rights: Copyright status unknown
DOI: 10.1136/hrt.61.2.139
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