Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/106411
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dc.contributor.authorYu, C.en
dc.contributor.authorBaune, B.en
dc.contributor.authorLicinio, J.en
dc.contributor.authorWong, M.en
dc.date.issued2017en
dc.identifier.citationPsychiatry Research, 2017; 252:75-79en
dc.identifier.issn0165-1781en
dc.identifier.issn1872-7123en
dc.identifier.urihttp://hdl.handle.net/2440/106411-
dc.descriptionAvailable online 20 February 2017en
dc.description.abstractRecent advances in DNA technologies have provided unprecedented opportunities for biological and medical research. In contrast to current popular genotyping platforms which identify specific variations, whole-genome sequencing (WGS) allows for the detection of all private mutations within an individual. Major depressive disorder (MDD) is a chronic condition with enormous medical, social and economic impacts. Genetic analysis, by identifying risk variants and thereby increasing our understanding of how MDD arises, could lead to improved prevention and the development of new and more effective treatments. Here we investigated the distributions of whole-genome single nucleotide variants (SNVs) on 12 different genomic regions for 25 human subjects using the symmetrised Kullback-Leibler divergence to measure the similarity between their SNV distributions. We performed cluster analysis for MDD patients and ethnically matched healthy controls. The results showed that Mexican-American controls grouped closer; in contrast depressed Mexican-American participants grouped away from their ethnically matched controls. This implies that whole-genome SNV distribution on the genomic regions may be related to major depression.en
dc.description.statementofresponsibilityChenglong Yu, Bernhard T. Baune, Julio Licinio, Ma-Li Wongen
dc.language.isoenen
dc.publisherElsevier BVen
dc.rights© 2017 Elsevier B.V. All rights reserved.en
dc.subjectMajor depressive disorder; Mexican-American; Whole-genome sequencing; Kullback-Leibler divergence; Cluster analysisen
dc.titleWhole-genome single nucleotide variant distribution on genomic regions and its relationship to major depressionen
dc.typeJournal articleen
dc.identifier.rmid0030065904en
dc.identifier.doi10.1016/j.psychres.2017.02.041en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1051931en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1060524en
dc.identifier.pubid290519-
pubs.library.collectionPsychiatry publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidYu, C. [0000-0002-3248-8421]en
dc.identifier.orcidBaune, B. [0000-0001-6548-426X]en
dc.identifier.orcidLicinio, J. [0000-0001-6905-5884]en
dc.identifier.orcidWong, M. [0000-0003-1512-3073]en
Appears in Collections:Psychiatry publications

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