Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/106144
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Type: Journal article
Title: Tuning chemistry and topography of nanoengineered surfaces to manipulate immune response for bone regeneration applications
Author: Chen, Z.
Bachhuka, A.
Han, S.
Wei, F.
Lu, S.
Visalakshan, R.
Vasilev, K.
Xiao, Y.
Citation: ACS Nano, 2017; 11(5):4494-4506
Publisher: ACS Publications
Issue Date: 2017
ISSN: 1936-0851
1936-086X
Statement of
Responsibility: 
Zetao Chen, Akash Bachhuka, Shengwei Han, Fei Wei, Shifeier Lu, Rahul Madathiparambil Visalakshan, Krasimir Vasilev and Yin Xiao
Abstract: Osteoimmunomodulation has informed the importance of modulating a favorable osteoimmune environment for successful materials-mediated bone regeneration. Nanotopography is regarded as a valuable strategy for developing advanced bone materials, due to its positive effects on enhancing osteogenic differentiation. In addition to this direct effect on osteoblastic lineage cells, nanotopography also plays a vital role in regulating immune responses, which makes it possible to utilize its immunomodulatory properties to create a favorable osteoimmune environment. Therefore, the aim of this study was to advance the applications of nanotopography with respect to its osteoimmunomodulatory properties, aiming to shed further light on this field. We found that tuning the surface chemistry (amine or acrylic acid) and scale of the nanotopography (16, 38, and 68 nm) significantly modulated the osteoimmune environment, including changes in the expression of inflammatory cytokines, osteoclastic activities, and osteogenic, angiogenic, and fibrogenic factors. The generated osteoimmune environment significantly affected the osteogenic differentiation of bone marrow stromal cells, with carboxyl acid-tailored 68 nm surface nanotopography offering the most promising outcome. This study demonstrated that the osteoimmunomodulation could be manipulated via tuning the chemistry and nanotopography, which implied a valuable strategy to apply a "nanoengineered surface" for the development of advanced bone biomaterials with favorable osteoimmunomodulatory properties.
Keywords: bone regeneration; inflammation; osteoimmunomodulation; surface chemistry; surface nanotopography
Rights: Copyright © 2017 American Chemical Society
RMID: 0030068727
DOI: 10.1021/acsnano.6b07808
Grant ID: http://purl.org/au-research/grants/nhmrc/1032738
http://purl.org/au-research/grants/nhmrc/1122825
http://purl.org/au-research/grants/arc/DP120103697
http://purl.org/au-research/grants/arc/DP150104212
Appears in Collections:Chemistry and Physics publications

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