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https://hdl.handle.net/2440/105614
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Type: | Journal article |
Title: | Imaging nuclear, endoplasmic reticulum and plasma membrane events in real time |
Author: | Bader, C. Sorvina, A. Simpson, P. Wright, P. Stagni, S. Plush, S. Massi, M. Brooks, D. |
Citation: | FEBS Letters, 2016; 590(18):3051-3060 |
Publisher: | Wiley-Blacwell |
Issue Date: | 2016 |
ISSN: | 0014-5793 1873-3468 |
Statement of Responsibility: | Christie A. Bader, Alexandra Sorvina, Peter V. Simpson, Phillip J. Wright, Stefano Stagni, Sally E. Plush, Massimiliano Massi and Douglas A. Brooks |
Abstract: | Live cell imaging can provide important information on cellular dynamics; however, the full utilisation of this technology has been hampered by the limitations of imaging reagents. Metal-based complexes have the potential to overcome many of the issues common to many current imaging agents. The rhenium (I)-based complex fac-[Re(CO)3 (1,10-phenanthroline)(4-pyridyltetrazolate)], herein referred to as ReZolve-ER(™) , shows promise as a live cell imaging agent with rapid cell uptake, low cytotoxicity, resistance to photobleaching and compatibility with multicolour imaging. ReZolve-ER(™) localised to the nuclear membrane/endoplasmic reticulum (ER) and allowed the detection of exocytotic events at the plasma membrane. Thus, we present a new imaging agent for monitoring live cell events in real time, which is ideal for imaging either short- or long-time courses. |
Keywords: | Endoplasmic reticulum; live cell imaging; rhenium |
Rights: | © 2016 Federation of European Biochemical Societies |
DOI: | 10.1002/1873-3468.12365 |
Grant ID: | http://purl.org/au-research/grants/arc/FT130100033 |
Published version: | http://dx.doi.org/10.1002/1873-3468.12365 |
Appears in Collections: | Aurora harvest 3 Biochemistry publications |
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