Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/105473
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zukotynski, K. | - |
dc.contributor.author | Kim, C. | - |
dc.contributor.author | Gerbaudo, V. | - |
dc.contributor.author | Hainer, J. | - |
dc.contributor.author | Taplin, M.-E. | - |
dc.contributor.author | Kantoff, P. | - |
dc.contributor.author | den Abbeele, A. | - |
dc.contributor.author | Seltzer, S. | - |
dc.contributor.author | Sweeney, C. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | American Journal of Nuclear Medicine and Molecular Imaging, 2015; 5(1):72-82 | - |
dc.identifier.issn | 2160-8407 | - |
dc.identifier.issn | 2160-8407 | - |
dc.identifier.uri | http://hdl.handle.net/2440/105473 | - |
dc.description | PMCID: PMC4299771 | - |
dc.description.abstract | To evaluate (18)F-labeled-fluorodeoxyglucose ((18)F-FDG-) and (18)F-labeled-sodium fluoride ((18)F-NaF-) positron emission tomography/computed tomography (PET/CT) as biomarkers in metastatic castrate-resistant prostate cancer (mCRPC). Nine men (53-75 years) in a phase 1 trial of abiraterone and cabozantinib had (18)F-FDG-PET/CT, (18)F-NaF-PET/CT and standard imaging ((99m)Tc-labeled-methylene-diphosphonate ((99m)Tc-MDP) bone scan and abdominal/pelvic CT) at baseline and after 8 weeks of therapy. Baseline disease was classified as widespread (18)F-FDG-avid, oligometastatic (18)F-FDG-avid (1 site), or non-(18)F-FDG-avid. Metabolic response was classified using European Organisation for Research and Treatment of Cancer (EORTC) criteria. Treatment response using Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, Prostate Cancer Working Group 2 (PCWG2) guidelines and days on trial (DOT) were recorded. All men were followed for 1 year or until progression. Four men had (18)F-FDG-avid disease: two with widespread (DOT 53 and 76) and two with oligometastatic disease (DOT 231 and still on trial after 742+ days). Five men had non-(18)F-FDG-avid disease; three remained stable or improved (2 still on trial while one discontinued for non-oncologic reasons; DOT 225-563+), and 2 progressed (DOT 285 and 532). Despite the small sample size, Kaplan-Meier analysis showed a significant difference in progression free survival (PFS) between men with widespread (18)F-FDG-avid, oligometastatic (18)F-FDG-avid and non-(18)F-FDG-avid disease (p < 0.01). All men had (18)F-NaF-avid disease. Neither (18)F-NaF-avid disease extent nor intensity was predictive of treatment response. (18)F-FDG-PET/CT may be superior to (18)F-NaF-PET/CT and standard imaging in men with mCRPC on abiraterone and cabozantinib. (18)F-FDG-PET/CT may have potential to stratify men into 3 groups (widespread vs. oligometastatic (18)F-FDG-avid vs. non-(18)F-FDG-avid mCRPC) to tailor therapy. Further evaluation is warranted. | - |
dc.description.statementofresponsibility | Katherine A Zukotynski, Chun K Kim, Victor H Gerbaudo, Jon Hainer, Mary-Ellen Taplin, Philip Kantoff, Annick D Van den Abbeele, Steven Seltzer, Christopher J Sweeney | - |
dc.language.iso | en | - |
dc.publisher | e-Century Publishing Corporation | - |
dc.rights | AJNMMI Copyright © 2015 | - |
dc.source.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299771/ | - |
dc.subject | FDG | - |
dc.subject | NaF | - |
dc.subject | PET/CT | - |
dc.subject | bone scan | - |
dc.subject | prostate cancer | - |
dc.title | ¹⁸F-FDG-PET/CT and ¹⁸F-NaF-PET/CT in men with castrate-resistant prostate cancer | - |
dc.title.alternative | (18)F-FDG-PET/CT and (18)F-NaF-PET/CT in men with castrate-resistant prostate cancer | - |
dc.type | Journal article | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Sweeney, C. [0000-0002-0398-6018] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.