Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/105180
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Type: Journal article
Title: Ghrelin, CCK, GLP-1, and PYY(3-36): secretory controls and physiological roles in eating and glycemia in health, obesity, and after RYGB
Author: Steinert, R.
Feinle-Bisset, C.
Asarian, L.
Horowitz, M.
Beglinger, C.
Geary, N.
Citation: Physiological Reviews, 2017; 97(1):411-463
Publisher: American Physiological Society
Issue Date: 2017
ISSN: 0031-9333
1522-1210
Statement of
Responsibility: 
Robert E. Steinert, Christine Feinle-Bisset, Lori Asarian, Michael Horowitz, Christoph Beglinger, Nori Geary
Abstract: The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the management of obesity and type 2 diabetes mellitus and novel developments in gastrointestinal (GI) endocrinology have renewed interest in the roles of GI hormones in the control of eating, meal-related glycemia, and obesity. Here we review the nutrient-sensing mechanisms that control the secretion of four of these hormones, ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), and peptide tyrosine tyrosine [PYY(3-36)], and their contributions to the controls of GI motor function, food intake, and meal-related increases in glycemia in healthy-weight and obese persons, as well as in RYGB patients. Their physiological roles as classical endocrine and as locally acting signals are discussed. Gastric emptying, the detection of specific digestive products by small intestinal enteroendocrine cells, and synergistic interactions among different GI loci all contribute to the secretion of ghrelin, CCK, GLP-1, and PYY(3-36). While CCK has been fully established as an endogenous endocrine control of eating in healthy-weight persons, the roles of all four hormones in eating in obese persons and following RYGB are uncertain. Similarly, only GLP-1 clearly contributes to the endocrine control of meal-related glycemia. It is likely that local signaling is involved in these hormones' actions, but methods to determine the physiological status of local signaling effects are lacking. Further research and fresh approaches are required to better understand ghrelin, CCK, GLP-1, and PYY(3-36) physiology; their roles in obesity and bariatric surgery; and their therapeutic potentials.
Keywords: Cholecystokinin
Rights: Copyright © 2017 the American Physiological Society
RMID: 0030060748
DOI: 10.1152/physrev.00031.2014
Grant ID: http://purl.org/au-research/grants/nhmrc/627002
Appears in Collections:Medicine publications

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