Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/104031
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dc.contributor.author | Barden, A. | - |
dc.contributor.author | O Callaghan, N. | - |
dc.contributor.author | Burke, V. | - |
dc.contributor.author | Mas, E. | - |
dc.contributor.author | Beilin, L.J. | - |
dc.contributor.author | Fenech, M. | - |
dc.contributor.author | Irish, A.B. | - |
dc.contributor.author | Watts, G.F. | - |
dc.contributor.author | Puddey, I.B. | - |
dc.contributor.author | Huang, R.C. | - |
dc.contributor.author | Mori, T.A. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Nutrients, 2016; 8(3):1-11 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2440/104031 | - |
dc.description.abstract | DNA telomere shortening associates with the age-related increase cardiovascular disease (CVD) risk. Reducing oxidative stress, could modify telomere erosion during cell replication, and CVD risk in patients with chronic kidney disease (CKD). The effect of n-3 fatty acids and coenzyme Q10 (CoQ) on telomere length was studied in a double-blind placebo-controlled trial in CKD. Eighty-five CKD patients were randomized to: n-3 fatty acids (4 g); CoQ (200 mg); both supplements; or control (4 g olive oil), daily for 8 weeks. Telomere length was measured in neutrophils and peripheral blood mononuclear cells (PBMC) at baseline and 8 weeks, with and without correction for cell counts. Main and interactive effects of n-3 fatty acids and CoQ on telomere length were assessed adjusting for baseline values. F2-isoprostanes were measured as markers of oxidative stress. There was no effect of n-3 fatty acids or CoQ on neutrophil or PBMC telomere length. However, telomere length corrected for neutrophil count was increased after n-3 fatty acids (p = 0.015). Post-intervention plasma F2-isoprostanes were negative predictors of post-intervention telomere length corrected for neutrophil count (p = 0.025).The effect of n-3 fatty acids to increased telomere length corrected for neutrophil count may relate to reduced oxidative stress and increased clearance of neutrophils with shorter telomeres from the circulation. This may be a novel mechanism of modifying CVD risk in CKD patients. | - |
dc.description.statementofresponsibility | Anne Barden, Nathan O'Callaghan, Valerie Burke, Emile Mas, Lawrence J. Beilin, Michael Fenech, Ashley B. Irish, Gerald F. Watts, Ian B. Puddey, Rae-Chi Huang and Trevor A. Mori | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.rights | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.source.uri | http://dx.doi.org/10.3390/nu8030175 | - |
dc.subject | neutrophils; telomere length; oxidative stress; n-3 fatty acids; coenzyme Q10 | - |
dc.title | n-3 fatty acid supplementation and leukocyte telomere length in patients with chronic kidney disease | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.3390/nu8030175 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/303151 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1010495 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Mas, E. [0000-0003-2848-9613] | - |
dc.identifier.orcid | Fenech, M. [0000-0002-8466-0991] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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hdl_104031.pdf | Published version | 577.88 kB | Adobe PDF | View/Open |
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