Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/100726
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Type: | Journal article |
Title: | The use of MALDI-MSI in the investigation of psychiatric and neurodegenerative disorders: a review |
Author: | Schubert, K. Weiland, F. Baune, B. Hoffmann, P. |
Citation: | Proteomics, 2016; 16(11-12):1747-1758 |
Publisher: | Wiley-VCH Verlag |
Issue Date: | 2016 |
ISSN: | 1615-9853 1615-9861 |
Editor: | Clench, M. |
Statement of Responsibility: | Klaus Oliver Schubert, Florian Weiland, Bernhard T. Baune and Peter Hoffmann |
Abstract: | Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a mass spectrometry technique used for the analysis of macromolecules on an intact tissue of interest, thereby allowing the assessment of molecular signatures in health and disease in the anatomical context. MALDI-MSI is increasingly used to investigate neurodegenerative and psychiatric disorders at the molecular level, including Alzheimer's disease (AD), Parkinson's disease (PD), and schizophrenia (SCZ). These illnesses are characterized by complex neuropathological processes, and conventional proteomic techniques investigating brain tissue homogenates have inherent limitations in determining the precise anatomical or cellular location of proteomic findings. In this article, we review MALDI-MSI studies on neurodegenerative and psychiatric disorders, and explore whether the technique could accelerate the translation of proteomic information into improved understanding and ultimately better therapeutic applications. |
Keywords: | Biomedicine; Imaging; MALDI-MSI; Mass spectrometry; Neurodegenerative disorders; Proteomics |
Description: | First published: 17 May 2016 |
Rights: | © 2016 The Authors. Proteomics Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1002/pmic.201500460 |
Published version: | http://dx.doi.org/10.1002/pmic.201500460 |
Appears in Collections: | Aurora harvest 3 IPAS publications |
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hdl_100726.pdf | Published version | 607.65 kB | Adobe PDF | View/Open |
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