Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/100630
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Type: | Journal article |
Title: | Oocyte maturation and quality: role of cyclic nucleotides |
Author: | Gilchrist, R. Luciano, A. Richani, D. Zeng, H. Wang, X. De Vos, M. Sugimura, S. Smitz, J. Richard, F. Thompson, J. |
Citation: | Reproduction, 2016; 152(5):R143-R157 |
Publisher: | BioScientifica |
Issue Date: | 2016 |
ISSN: | 1470-1626 1741-7899 |
Statement of Responsibility: | Gilchrist RB, Luciano AM, Richani D, Zeng HT, Wang X, De Vos M, Sugimura S, Smitz J, Richard FJ and Thompson JG |
Abstract: | The cyclic nucleotides, cAMP and cGMP, are the key molecules controlling mammalian oocyte meiosis. Their roles in oocyte biology have been at the forefront of oocyte research for decades and many of the long standing controversies in relation to the regulation of oocyte meiotic maturation are now resolved. It is now clear that the follicle prevents meiotic resumption through the actions of natriuretic peptides and cGMP inhibiting the hydrolysis of intra-oocyte cAMP and that the preovulatory gonadotrophin surge reverses these processes. The gonadotrophin surge also leads to a transient spike in cAMP in the somatic compartment of the follicle; research over the past 2 decades has conclusively demonstrated that this surge in cAMP is important for the subsequent developmental capacity of the oocyte. This is important, as oocyte in vitro maturation (IVM) systems practiced clinically do not recapitulate this cAMP surge in vitro, possibly accounting for the lower efficiency of IVM compared to clinical IVF. This review focuses in particular on this latter aspect - the role of cAMP/cGMP in the regulation of oocyte quality. We conclude that clinical practice of IVM should reflect this new understanding of the role of cyclic nucleotides, thereby creating a new generation of ART and fertility treatment options. |
Keywords: | Oocytes Animals Humans Nucleotides, Cyclic Oogenesis Female In Vitro Oocyte Maturation Techniques |
Description: | Advance Publication first posted online on 15 July 2016 - Accepted manuscript |
Rights: | Copyright © 2016 Society for Reproduction and Fertility |
DOI: | 10.1530/REP-15-0606 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1007551 http://purl.org/au-research/grants/nhmrc/627007 http://purl.org/au-research/grants/nhmrc/1008137 http://purl.org/au-research/grants/nhmrc/1023210 |
Published version: | http://dx.doi.org/10.1530/rep-15-0606 |
Appears in Collections: | Aurora harvest 3 IPAS publications |
Files in This Item:
File | Description | Size | Format | |
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hdl_100630.pdf | Accepted Version | 1.63 MB | Adobe PDF | View/Open |
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