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PreviewIssue DateTitleAuthor(s)
2019OBI-3424, a novel AKR1c3-activated prodrug, exhibits potent efficacy against preclinical models of T-ALLEvans, K.; Duan, J.X.; Pritchard, T.; Jones, C.D.; McDermott, L.; Gu, Z.; Toscan, C.E.; El-Zein, N.; Mayoh, C.; Erickson, S.W.; Guo, Y.; Meng, F.; Jung, D.; Rathi, K.S.; Roberts, K.G.; Mullighan, C.G.; Shia, C.S.; Pearce, T.; Teicher, B.A.; Smith, M.A.; et al.
2019Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmissionGuo, H.; Li, Y.; Shen, L.; Wang, T.; Jia, X.; Liu, L.; Xu, T.; Ou, M.; Hoekzema, K.; Wu, H.; Gillentine, M.A.; Liu, C.; Ni, H.; Peng, P.; Zhao, R.; Zhang, Y.; Phornphutkul, C.; Stegmann, A.P.A.; Prada, C.E.; Hopkin, R.J.; et al.
2019Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran sulphate sodium-induced ulcerative colitisKopecki, Z.; Yang, G.; Treloar, S.; Mashtoub, S.; Howarth, G.S.; Cummins, A.G.; Cowin, A.J.
2019Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in femalesJackson, M.R.; Loring, K.E.; Homan, C.C.; Thai, H.N.; Määttänen, L.; Arvio, M.; Jarvela, I.; Shaw, M.; Gardner, A.; Gecz, J.; Shoubridge, C.
2019Intermittent fasting improves glucose tolerance and promotes adipose tissue remodeling in male mice fed a high-fat dietLiu, B.; Page, A.J.; Hatzinikolas, G.; Chen, M.; Wittert, G.A.; Heilbronn, L.K.
2019Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivityCastro, J.; Harrington, A.M.; Lieu, T.; Garcia Caraballo, S.; Maddern, J.; Schober, G.; O'Donnell, T.; Grundy, L.; Lumsden, A.L.; Miller, P.E.; Ghetti, A.; Steinhoff, M.S.; Poole, D.P.; Dong, X.; Chang, L.; Bunnett, N.W.; Brierley, S.M.
2019Alpha-Blockers as colorectal cancer chemopreventive: findings from a case-control study, human cell cultures, and in vivo preclinical testingSuzuki, N.; Niikura, R.; Ihara, S.; Hikiba, Y.; Kinoshita, H.; Higashishima, N.; Hayakawa, Y.; Yamada, A.; Hirata, Y.; Nakata, R.; Okamoto, M.; Sano, M.; Kushiyama, A.; Ichinose, M.; Woods, S.L.; Worthley, D.; Iwamoto, Y.; Koike, K.
2019Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemiaMoujalled, D.M.; Pomilio, G.; Ghiurau, C.; Ivey, A.; Salmon, J.; Rijal, S.; Macraild, S.; Zhang, L.; Teh, T.C.; Tiong, I.S.; Lan, P.; Chanrion, M.; Claperon, A.; Rocchetti, F.; Zichi, A.; Kraus-Berthier, L.; Wang, Y.; Halilovic, E.; Morris, E.; Colland, F.; et al.

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