DSpace Collection:https://hdl.handle.net/2440/475382024-03-29T05:22:04Z2024-03-29T05:22:04ZNon-pharmacological interventions for the treatment of canine cognitive dysfunction: A scoping reviewTaylor, T.L.Fernandez, E.J.Handley, K.N.Hazel, S.J.https://hdl.handle.net/2440/1403242024-01-11T23:06:59Z2023-01-01T00:00:00ZTitle: Non-pharmacological interventions for the treatment of canine cognitive dysfunction: A scoping review
Author: Taylor, T.L.; Fernandez, E.J.; Handley, K.N.; Hazel, S.J.
Abstract: Canine cognitive dysfunction (CCD) is a neurodegenerative disease, likened to Alzheimer's, most commonly seen in dogs over the age of 10 years. CCD is difficult to diagnose and there is no cure, consequently research efforts are focused on maintaining a good quality of life for these dogs for as long as possible. Our scoping review aimed to identify, critically appraise, and map the existing literature on the impact of non-pharmacological treatments for CCD. We followed a systematic approach and utilised established tools to assess the literature. Thirty-one papers were extracted for full review. Of these, 29 investigated supplements or diets as their intervention, with the most common a combination of antioxidants and omega 3 fatty acids, which are known for their neuroprotective qualities. There were almost twice as many experiments conducted on laboratory dogs than on pet dogs. The inclusion and exclusion criteria for each study varied widely and was often not well-defined, making comparisons between treatments difficult. This scoping review highlights the need for an accepted measure to determine the presence of CCD, standardised testing methods for cognitive ability in senior canines that translates between laboratory and pet dog populations, and a broader view of non-pharmacological interventions that go beyond supplements or diets.2023-01-01T00:00:00ZAntimicrobial and healing promoting properties of animal and plant oils for treatment of infected woundsTahlia, K.Mashtoub, S.Howarth, G.Allison, C.Kopecki, Z.https://hdl.handle.net/2440/1400572023-12-04T23:29:40Z2019-01-01T00:00:00ZTitle: Antimicrobial and healing promoting properties of animal and plant oils for treatment of infected wounds
Author: Tahlia, K.; Mashtoub, S.; Howarth, G.; Allison, C.; Kopecki, Z.
Abstract: Chronic wounds are a serious medical problem both in the hospital and community setting. The healing of chronic wounds is often compromised by colonisation of different bacterial pathogens leading to life-threatening infections. Bacterial infections are a critical contributing factor to chronic wounds and can lead to biofilm formation and inhibition of innate inflammatory responses, including the reduction of acute inflammation. Concerningly, the overuse of systemic antibiotics and the use of traditional therapeutics, including topical antimicrobials – iodine, chlorhexidine and silver – have both greatly contributed to the development of a global increase in antimicrobial resistance. This has therefore led to a renewed interest in natural and alternative antimicrobial treatment strategies in wound care for the treatment of infected wounds. This review summarises the pre-clinical and clinical evidence that exists for the use of natural remedies, namely essential and animal oils, as adjunctive therapeutic approaches for the treatment of infected wounds. It also discusses novel approaches in nanotechnology that are being used for the development of natural remedies aimed at improving the healing of infected chronic wounds.2019-01-01T00:00:00ZDiagnostic approaches, aetiological agents and their associations with short-term survival and laminitis in horses with acute diarrhoea admitted to referral institutionsGomez, D.Arroyo, L.G.Schoster, A.Renaud, D.L.Kopper, J.J.Dunkel, B.Byrne, D.Mykkanen, A.Gilsenan, W.F.Pihl, T.H.Lopez, G.Tennent-Brown, B.S.Hostnik, L.D.Mora-Pereira, M.Marquez, F.Gold, J.R.DeNotta, S.L.Desjardins, I.Stewart, A.J.Kuroda, T.et al.https://hdl.handle.net/2440/1400292023-12-06T03:36:22Z2023-01-01T00:00:00ZTitle: Diagnostic approaches, aetiological agents and their associations with short-term survival and laminitis in horses with acute diarrhoea admitted to referral institutions
Author: Gomez, D.; Arroyo, L.G.; Schoster, A.; Renaud, D.L.; Kopper, J.J.; Dunkel, B.; Byrne, D.; Mykkanen, A.; Gilsenan, W.F.; Pihl, T.H.; Lopez, G.; Tennent-Brown, B.S.; Hostnik, L.D.; Mora-Pereira, M.; Marquez, F.; Gold, J.R.; DeNotta, S.L.; Desjardins, I.; Stewart, A.J.; Kuroda, T.; et al.
Abstract: Background: An international description of the diagnostic approaches used in different institutions to diagnose acute equine diarrhoea and the pathogens detected is lacking. Objectives: To describe the diagnostic approach, aetiological agents, outcome, and development of laminitis for diarrhoeic horses worldwide. Study design: Multicentre retrospective case series. Methods: Information from horses with acute diarrhoea presenting to participating institutions between 2016 and 2020, including diagnostic approaches, pathogens detected and their associations with outcomes, were compared between institutions or geographic regions. Results: One thousand four hundred and thirty-eight horses from 26 participating institutions from 4 continents were included. Overall, aetiological testing was limited (44% for Salmonella spp., 42% for Neorickettsia risticii [only North America], 40% for Clostridiodes difficile, and 29% for ECoV); however, 13% (81/633) of horses tested positive for Salmonella, 13% (35/262) for N. risticii, 9% (37/422) for ECoV, and 5% (27/578) for C. difficile. C. difficile positive cases had greater odds of non-survival than horses negative for C. difficile (OR: 2.69, 95%CI: 1.23–5.91). In addition, horses that were positive for N. risticii had greater odds of developing laminitis than negative horses (OR: 2.76, 95%CI: 1.12–6.81; p = 0.029). Main limitations: Due to the study's retrospective nature, there are missing data. Conclusions: This study highlighted limited diagnostic investigations in cases of acute equine diarrhoea. Detection rates of pathogens are similar to previous reports. Nonsurvival and development of laminitis are related to certain detected pathogens.
Description: First published: 20 November 2023.
OnlinePubl2023-01-01T00:00:00Z"Chemobrain" in childhood cancer survivors - the impact on social, academic, and daily living skills: a qualitative systematic reviewSemendric, I.Pollock, D.Haller, O.George, R.Collins-Praino, L.Whittaker, A.https://hdl.handle.net/2440/1399132023-11-19T22:43:51Z2023-01-01T00:00:00ZTitle: "Chemobrain" in childhood cancer survivors - the impact on social, academic, and daily living skills: a qualitative systematic review
Author: Semendric, I.; Pollock, D.; Haller, O.; George, R.; Collins-Praino, L.; Whittaker, A.
Abstract: Purpose: To examine children’s experiences of chemotherapy-induced cognitive impairment––colloquially “chemobrain”–– and the impact on children’s social, academic, and daily living skills via a qualitative systematic review. Experiencing chemotherapy as a child, when the brain is still developing, may cause lifelong detriment to survivors’ lives. There is a significant gap in understanding their lived experience, including the self-identified barriers that children face following treatment. Such a gap can only be fully bridged by listening to the child’s own voice and/or parent proxy report through an exploration of the qualitative research literature. Methods: A search of MEDLINE, Embase, PsycINFO, and CINAHL databases was conducted. Inclusion criteria were qualitative studies with a focus on children (0–18 years) during and/or following chemotherapy treatment and explored children’s experiences of chemobrain. Results: Two synthesized findings were identified from six studies. (1) Chemobrain has an academic and psychosocial impact, which may not be understood by education providers. (2) Children and their parents have concerns about their reintegration and adaptation to school, social lives, and their future selves as independent members of society. Children’s experiences primarily related to changes in their academic and social functioning. Conclusion: This review highlights two important considerations: (1) the lived experiences of pediatric childhood cancer survivors guiding where future interventions should be targeted, and (2) a need to perform more qualitative research studies in this area, as well as to improve the quality of reporting among the existing literature, given that this is a current gap in the field.
Description: Published online: 22 August 20232023-01-01T00:00:00Z