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https://hdl.handle.net/2440/51931
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Type: | Journal article |
Title: | Pharmacokinetic-pharmacodynamic relationships of cognitive and psychomotor effects of intravenous buprenorphine infusion in human volunteers |
Author: | Jensen, M. Sjogren, P. Upton, R. Foster, D. Bonde, P. Graae, C. Skram, U. Stevner, L. Christrup, L. |
Citation: | Basic and Clinical Pharmacology and Toxicology, 2008; 103(1):94-101 |
Publisher: | Munksgaard Int Publ Ltd |
Issue Date: | 2008 |
ISSN: | 1742-7835 1742-7843 |
Statement of Responsibility: | Mette L. Jensen, Per Sjøgren, Richard N. Upton, David J. R. Foster, Peter Bonde, Christian Graae, Ulrik Skram, Lene Stevner and Lona L. Christrup |
Abstract: | The main objective of the present study was to characterize the pharmacokinetic/pharmacodynamic (PK/PD) relationship of the effects of buprenorphine on cognitive functioning in healthy volunteers. Twenty-three male volunteers received 0.6 mg buprenorphine as an intravenous infusion over 150 min. The cognitive and psychomotor performance was evaluated before and at various times after drug administration by a test battery consisting of trail-making test for visual information processing, finger-tapping test for psychomotor speed, and continuous reaction time for attention. Non-linear mixed effect modelling was used in the analysis of the PK/PD relationships. Buprenorphine caused significant deficits in cognitive and psychomotor functioning. The time course of cognitive and psychomotor impairment was found to have a slow distribution to the biophase from plasma with PK/PD models involving an effect compartment providing the best descriptions of the time course of the data. The values for half-life of biophase equilibration were consistent between the neuropsychological tests in the range of 66.6-84.9 min. The time to onset and duration of the cognitive and psychomotor impairment of buprenorphine was determined by a slow distribution to the biophase. |
Keywords: | Humans Buprenorphine Analgesics, Opioid Infusions, Intravenous Cognition Psychomotor Performance Psychological Tests Nonlinear Dynamics Half-Life Adult Male |
DOI: | 10.1111/j.1742-7843.2008.00250.x |
Published version: | http://dx.doi.org/10.1111/j.1742-7843.2008.00250.x |
Appears in Collections: | Aurora harvest 5 Pharmacology publications |
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